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Peptide record

TPDB63132

IRF5-CPP3 Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB63132
IRF5-CPP3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 28-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
MANLGYWLLLLFVTMWTDVGLAKKRPKP
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C156H245N37O35S2
CEQHIS
L
3263.01
10.46
4
1
16
+3
-0.12
0.346
111.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12490
3.83
4
Residue Composition
number
2
A
1
R
1
N
1
D
0
C
0
E
0
Q
2
G
0
H
0
I
6
L
3
K
2
M
1
F
2
P
0
S
2
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 6 K: 3 M: 2 F: 1 P: 2 S: 0 T: 2 W: 2 Y: 1 V: 2
Chemical Descriptors
28 reviewed residue count
C156H245N37O35S2 sequence-only estimate (linear, free termini)
3263.01 sequence-only estimate (linear, free termini)
10.46 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
-0.12 sequence-only estimate (linear, free termini)
0.346 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PBMCs, Cd19+ B Cells, Cd14+ Monocytes, And Bdca2+Cd123+ Plasmacytoid Dendritic Cells (Pdcs), HeLa And THP-1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
FITC dye
In vitro
CCSSCCC
Additional Detail Fields 1 fields
CCSSCCC