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Peptide record

TPDB63128

Human Prp (1-28) Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB63128
Human Prp (1-28)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with fluorescein
Sequence
MANLGCWMLVLFVATWSDLGLCKKRPKP-NH2
Physicochemical Analysis
C146H233N37O34S4
EQHIY
L
3178.92
9.80
4
1
14
+3
-2.15
0.432
97.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11125
349.96
5
Residue Composition
number
2
A
1
R
1
N
1
D
2
C
0
E
0
Q
2
G
0
H
0
I
5
L
3
K
2
M
1
F
2
P
1
S
1
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 1 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 5 K: 3 M: 2 F: 1 P: 2 S: 1 T: 1 W: 2 Y: 0 V: 2
Chemical Descriptors
28
C146H233N37O34S4
3178.92
9.80
+3
-2.15
0.432
Amidation
L
Amphipathic
Linear
Conjugation with fluorescein
N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human bowes melanoma, N1e neuroblastoma and N2A cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
Probably perinuclearly and in the cytosol
In vitro
CCCCSSSTTTSGGGGTSCSCSSCCCCCC
Additional Detail Fields 1 fields
CCCCSSSTTTSGGGGTSCSCSSCCCCCC