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Peptide record

TPDB63114

bdnf89-98-Tat Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB63114
bdnf89-98-Tat
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with 5-Carboxyfluorescein (5-Fam)
Sequence
LYTSRVMLSSYGRKKRRQRRR
Physicochemical Analysis
C114H201N45O29S1
ANDCEHIFPW
R
2698.19
12.53
9
0
6
+9
5.61
-1.676
50.95
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
2980
110.44
7
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
2
L
2
K
1
M
0
F
0
P
3
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 2 K: 2 M: 1 F: 0 P: 0 S: 3 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
21
C114H201N45O29S1
2698.19
12.53
+9
5.61
-1.676
Free
L
Linear
Conjugated with 5-Carboxyfluorescein (5-Fam)
N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293 Cells , Drg Neuronal Culture And Rat Cortical Neuronal Cultures

Assay & Model

Sprague-Dawley rats
Sprague-Dawley rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
Tat-tagged peptide could be efficiently transported to cells
In vitro and in vivo
CCCCSSTTSCCGGGGGGSCCC
Additional Detail Fields 1 fields
CCCCSSTTSCCGGGGGGSCCC