TPDB

3D PDB MODEL

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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB ID TPDB63114

Peptide_Name

bdnf89-98-Tat

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0

Sequence_Type

modified_plain

Has_Modification Yes

Description A 21-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.

Modification

N-terminal: Conjugated with 5-Carboxyfluorescein (5-Fam)

Sequence

LYTSRVMLSSYGRKKRRQRRR

FASTA

>TPDB63114|Cell-penetrating Peptides|length=21
LYTSRVMLSSYGRKKRRQRRR

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Length

21 reviewed residue count

C_terminal_Modification

Free Activity

Chirality

L Activity

Linearity

Linear Activity

N_terminal_Modification

Conjugated with 5-Carboxyfluorescein (5-Fam) Activity

SMILES

N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O Activity

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Hek293 Cells , Drg Neuronal Culture And Rat Cortical Neuronal Cultures

Assay & Model

In Vitro Model Sprague-Dawley rats

In Vivo Model Sprague-Dawley rats

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L

Source of Peptide Chimeric

Uptake Efficiency Tat-tagged peptide could be efficiently transported to cells

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCSSTTSCCGGGGGGSCCC

DSSP_Secondary_Structure

CCCCSSTTSCCGGGGGGSCCC