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Peptide record

TPDB63109

W1-2L Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB63109
W1-2L
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LWRLWRLLWRLWRLL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C110H167N31O16
ANDCEQGHIKMFPSTYV
L
2179.73
12.88
4
0
11
+4
1.06
0.333
182.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
22000
10.09
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
7
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 7 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
15 reviewed residue count
C110H167N31O16 sequence-only estimate (linear, free termini)
2179.73 sequence-only estimate (linear, free termini)
12.88 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
1.06 sequence-only estimate (linear, free termini)
0.333 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Amphipathic Activity
Linear Activity
Free Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Amphipathic
Synthetic
siRNA labelled with Alexa490
Low Fluorescence intensity compared to W1:siRNA and the W5:siRNA
Membrane translocation
In vitro