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Peptide record

TPDB63101

LSWSQ Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB63101
LSWSQ
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LSWSQTQGVSST
Physicochemical Analysis
C54H85N15O21
ARNDCEHIKMFPY
S
1280.36
6.02
0
0
3
-0
-0.37
-0.408
56.67
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
429.57
8
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
4
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 4 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
12
C54H85N15O21
1280.36
6.02
-0
-0.37
-0.408
Free
L
Linear
Free
N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mc3T3-E1 Cell Line, Caco-2 Cells,

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
eGFP at C terminus
Moderate uptake compared to the unmodified negative control eGFP in MC3TS-E1 cells but no uptake in Caco-2 cells
In vitro
CCCCSSCCSSCC
Additional Detail Fields 1 fields
CCCCSSCCSSCC