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Peptide record

TPDB63099

R8MTS Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB63099
R8MTS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Cysteine Chemical: N-(2-hydroxypropyl) methacrylamide (HPMA) ploymer
Sequence
LSRTRAAAPNSRIFTRRRRRRRRRC
Physicochemical Analysis
C128H234N62O31S1
DEQGHKMWYV
R
3169.72
13.10
12
0
6
+12
8.38
-1.724
43.20
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
6
Residue Composition
number
3
A
12
R
1
N
0
D
1
C
0
E
0
Q
0
G
0
H
1
I
1
L
0
K
0
M
1
F
1
P
2
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 12 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 1 S: 2 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
25
C128H234N62O31S1
3169.72
13.10
+12
8.38
-1.724
Addition of Cysteine
N-(2-hydroxypropyl) methacrylamide (HPMA) ploymer
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

4T1 And MDA-MB-231 Cells

Assay & Model

Female BALB/c mice (4-6 weeks)
Female BALB/c mice (4-6 weeks)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Doxorubicin (DOX)
Mitochondria
P-D-R8MTS showed enhanced cellular uptake with 1.51-fold higher than PD at 4 h.
More than one endocytosis pathways including macropinocytosis
In vitro and in vivo
CCSCTTGGGHHHHHHHTTSCCC
Additional Detail Fields 1 fields
CCSCTTGGGHHHHHHHTTSCCC