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Peptide record

TPDB63097

MTS Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB63097
MTS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: N-(2-hydroxypropyl) methacrylamide (HPMA) ploymer
Sequence
LSRTRAAAPNSRIFTRC
Physicochemical Analysis
C80H138N30O23S1
DEQGHKMWYV
R
1920.22
12.40
4
0
6
+4
1.90
-0.418
63.53
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
6
Residue Composition
number
3
A
4
R
1
N
0
D
1
C
0
E
0
Q
0
G
0
H
1
I
1
L
0
K
0
M
1
F
1
P
2
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 4 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 1 S: 2 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C80H138N30O23S1
1920.22
12.40
+4
1.90
-0.418
Free
N-(2-hydroxypropyl) methacrylamide (HPMA) ploymer
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

4T1 And MDA-MB-231 Cells

Assay & Model

Female BALB/c mice (4-6 weeks)
Female BALB/c mice (4-6 weeks)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Doxorubicin (DOX)
Mitochondria
P-D-MTS exhibited lower uptake at 4 h compared with PD
More than one endocytosis pathways including macropinocytosis
In vitro and in vivo
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC