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Peptide record

TPDB63090

A2-17KR Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB63090
A2-17KR
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-LRRLRRRLLRLWRLRRR-NH2
Physicochemical Analysis
C107H198N48O18
ANDCEQGHIKMFPSTYV
R
2445.06
13.35
10
0
7
+10
2.89
-1.359
137.65
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
224.94
0
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
6
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C107H198N48O18
2445.06
13.35
+10
2.89
-1.359
Amidation
L
Amphipathic
Linear
Acetylation
N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Wild Type CHO (CHO-K1) Cells And The Gag-Deficient CHO Cells (Pgsa-745)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
5(6)-carboxyfluorescein (FAM) via glycylglycine linker at N terminus
A2-17KR penetrates cell membranes less efficiently than A2-17
In vitro
CHHHHHHHTTTHHHHCC
Additional Detail Fields 1 fields
CHHHHHHHTTTHHHHCC