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Peptide record

TPDB63084

W5-2L Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB63084
W5-2L
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LRLLRWWWRLLRL
Physicochemical Analysis
C93H146N28O14
ANDCEQGHIKMFPSTYV
L
1880.36
12.88
4
0
9
+4
-5.67
0.162
180.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
16500
877.49
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
6
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
13
C93H146N28O14
1880.36
12.88
+4
-5.67
0.162
Free
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
siRNA labelled with Alexa492
No fluorescence was observed for W1-4R:siRNA and W5-2L:siRNA
Membrane translocation
In vitro
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC