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Peptide record

TPDB63080

A2-17 Cell-penetrating Peptides modified_plain modified
17 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB63080
A2-17
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 17-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-LRKLRKRLLRLWKLRKR-NH2
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
17 reviewed residue count
Amidation Activity
L Activity
Amphipathic Activity
Linear Activity
Acetylation Activity
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Wild Type CHO (CHO-K1) Cells And The Gag-Deficient CHO Cells (Pgsa-745)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
5(6)-carboxyfluorescein (FAM) via glycylglycine linker at N terminus
A2-17KR penetrates cell membranes less efficiently than A2-17
In vitro
CCCCTTTHHHHHHHTCC
Additional Detail Fields 1 fields
CCCCTTTHHHHHHHTCC