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Peptide record

TPDB63068

LRRK(21322−1340) Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB63068
LRRK(21322−1340)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acylation
Sequence
LQQRLKKAVPYNRMKLMIV-NH2
Physicochemical Analysis
C105H185N31O24S2
DCEGHFSTW
LK
2329.94
11.59
5
0
10
+5
3.20
-0.221
117.89
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
63.95
4
Residue Composition
number
1
A
2
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
1
I
3
L
3
K
2
M
0
F
1
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 1 L: 3 K: 3 M: 2 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
19
C105H185N31O24S2
2329.94
11.59
+5
3.20
-0.221
Amidation
L
Polycationic
Linear
Acylation
N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

T-Rex HEK-293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Polycationic
Synthetic
TAMRA-labelled at N terminus
Cytosol
TAMRA-LRRK21322-1340 accumulate and strongly co-localise with GFP-tagged LRRK2 protein with co-localisation coefficients (R) of 0.976 ±0.009.
In vitro
CCTTHHHHSSCCSSSCCCC
Additional Detail Fields 1 fields
CCTTHHHHSSCCSSSCCCC