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Peptide record

TPDB63066

PF4PD Cell-penetrating Peptides standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB63066
PF4PD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 35-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
LQAPLYKKIIKKLLESGGSGGAPLYKKIIKKLLES-NH2
Physicochemical Analysis
C180H310N44O46
RNDCHMFTWV
K
3826.71
10.44
8
2
15
+6
6.49
-0.094
128.29
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
2980
77.87
6
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
2
E
1
Q
4
G
0
H
4
I
7
L
8
K
0
M
0
F
2
P
3
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 1 G: 4 H: 0 I: 4 L: 7 K: 8 M: 0 F: 0 P: 2 S: 3 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
35
C180H310N44O46
3826.71
10.44
+6
6.49
-0.094
Amidation
L
Cationic
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mm96L And Hacat Cells MCF7 And MDA-MB-231 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
In vitro
CCCCHHHHHHHHHGGGSSSSSCHHHHHHHGGGTCC
Additional Detail Fields 1 fields
CCCCHHHHHHHHHGGGSSSSSCHHHHHHHGGGTCC