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Peptide record

TPDB63065

PF4P_pDI_A488 Cell-penetrating Peptides modified_plain modified
34 amino acids
Basic Information
3D PDB MODEL
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TPDB63065
PF4P_pDI_A488
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 34-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
LQAPLTFEHYWALLTSGGXGGAPLYKKIIKKLES-NH2
Physicochemical Analysis
C172H269N41O45
RNDCMV
L
3631.28
9.82
5
2
15
+2
1.67
-0.018
100.59
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
8480
233.53
7
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
2
E
1
Q
4
G
1
H
2
I
6
L
4
K
0
M
1
F
2
P
2
S
2
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 1 G: 4 H: 1 I: 2 L: 6 K: 4 M: 0 F: 1 P: 2 S: 2 T: 2 W: 1 Y: 2 V: 0
Chemical Descriptors
34
C172H269N41O45
3631.28
9.82
+2
1.67
-0.018
Amidation
Modified
Cationic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mm96L And Hacat Cells MCF7 And MDA-MB-231 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified Cationic
Synthetic
A488 dye
Cytoplasm
PF4P_pDI appeared to enter each of the different cell types with similar efficacy but less than other two.
In vitro