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Peptide record

TPDB63057

Peptide 44 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB63057
Peptide 44
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 12-aa standard-residue cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Sequence
LNVPPSWFLSQR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C68H102N18O17
ADCEGHIKMTY
LPS
1443.67
11.05
1
0
5
+1
1.23
-0.217
89.17
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
3.81
4
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
2
L
0
K
0
M
1
F
2
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 1 P: 2 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
12 reviewed residue count
C68H102N18O17 sequence-only estimate (linear, free termini)
1443.67 sequence-only estimate (linear, free termini)
11.05 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
1.23 sequence-only estimate (linear, free termini)
-0.217 sequence-only estimate (linear, free termini)
L Activity
Linear Activity
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human primary T cells

Source & Reference

CPPsite3.0
CPPsite3
US 6881825

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Phages
In vitro
CCCCTTCSSSCC
Additional Detail Fields 1 fields
CCCCTTCSSSCC