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Peptide record

TPDB63052

DCpep-4R8-NH2 Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB63052
DCpep-4R8-NH2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Addition of Methylated Cysteine Methylated
Sequence
LNRCVAKYHGYPWCRRRRRRRR-NH2
Physicochemical Analysis
C126H208N54O26S2
DEQIMFST
R
2959.50
12.31
11
0
6
+10
5.25
-1.900
35.45
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
8605
290.76
5
Residue Composition
number
1
A
9
R
1
N
0
D
2
C
0
E
0
Q
1
G
1
H
0
I
1
L
1
K
0
M
0
F
1
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 9 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
22
C126H208N54O26S2
2959.50
12.31
+10
5.25
-1.900
Amidation
L
Linear
Addition of Methylated Cysteine Methylated
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Luciferin
Cytosol
All luciferin-conjugated peptides showed a luminescence signal in a peptide-concentration dependent manner except for luciferin-DCpep-3-OH
In vitro
CCCSSSTTCCCTTTTC
Additional Detail Fields 1 fields
CCCSSSTTCCCTTTTC