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Peptide record

TPDB63028

W1-1P Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB63028
W1-1P
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LLWRLWRLPLWRLWRLL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C121H185N33O18
ANDCEQGHIKMFSTYV
L
2390.01
12.88
4
0
12
+4
0.65
0.424
183.53
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
22000
9.20
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
8
L
0
K
0
M
0
F
1
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
17 reviewed residue count
C121H185N33O18 sequence-only estimate (linear, free termini)
2390.01 sequence-only estimate (linear, free termini)
12.88 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.65 sequence-only estimate (linear, free termini)
0.424 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Amphipathic Activity
Linear Activity
Free Activity
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
siRNA labelled with Alexa494
A very lower internalisation for W1-1P and W5-2P.
Membrane translocation
In vitro
CCTTHHHHTTTTTTC
Additional Detail Fields 1 fields
CCTTHHHHTTTTTTC