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Peptide record

TPDB63023

W5 WRAP5 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB63023
W5 WRAP5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LLRLLRWWWRLLRLL
Physicochemical Analysis
C105H168N30O16
ANDCEQGHIKMFPSTYV
L
2106.68
12.88
4
0
11
+4
-6.79
0.647
208.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
16500
783.22
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
8
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
15
C105H168N30O16
2106.68
12.88
+4
-6.79
0.647
Free
L
Amphipathic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
siRNA labelled with Alexa489
High Fluorescence intensity compared to W1-2L:siRNA and W5-4R:siRNA
Membrane translocation
In vitro
CGGGGHHHHHHHHHHHHTCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Amphipathic
Synthetic
TAMRA-labeled and iCAL36 peptide
Cytoplasm and Intramembrane
In vitro
Additional Detail Fields 1 fields
CGGGGHHHHHHHHHHHHTCC