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Peptide record

TPDB63022

WRAP4 Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB63022
WRAP4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticles
Sequence
LLRLLRWWRLLRLL
Physicochemical Analysis
C94H158N28O15
ANDCEQGHIKMFPSTYV
L
1920.47
12.88
4
0
10
+4
-4.94
0.757
222.86
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
11000
572.78
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
8
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
14
C94H158N28O15
1920.47
12.88
+4
-4.94
0.757
Free
Nanoparticles
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87, Kb, MCF7, Huh7, Neuro2A, Cmt93, Ht29, Rm1 And MDA-MB-231 Cells,

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
siRNA
Not efficient siRNA cellular delivery
In vitro
CCCCCCCCCBCCTTSSSCCBCCC
Additional Detail Fields 1 fields
CCCCCCCCCBCCTTSSSCCBCCC