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Peptide record

TPDB63020

peptide 19 Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB63020
peptide 19
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LLRLKKYKVPQLE
Physicochemical Analysis
C77H134N20O18
ANDCGHIMFSTW
L
1628.03
10.46
4
1
6
+3
3.72
-0.515
142.31
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
91.52
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
0
I
4
L
3
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 0 L: 4 K: 3 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
13
C77H134N20O18
1628.03
10.46
+3
3.72
-0.515
Free
L
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells And J774.2 Mouse Macrophage Cell Lines.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
5-FAM at N terminal
Cytoplasm
All the peptides tested were internalised into the cells
Endocytosis
In vitro
CCTTTTTCCCCCCC
Additional Detail Fields 1 fields
CCTTTTTCCCCCCC