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Peptide record

TPDB63018

S9RH Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB63018
S9RH
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 18-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
LLRHLRRHIRRARRHIRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C105H191N51O19
NDCEQGKMFPSTWYV
R
2472.00
13.30
12
0
6
+9
6.77
-1.550
113.89
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
3
H
2
I
3
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 3 I: 2 L: 3 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18 reviewed residue count
C105H191N51O19 sequence-only estimate (linear, free termini)
2472.00 sequence-only estimate (linear, free termini)
13.30 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
6.77 sequence-only estimate (linear, free termini)
-1.550 sequence-only estimate (linear, free termini)
L Activity
Amphipathic Activity
Linear Activity
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 and WM266-1 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Nucleic acid (Plasmid DNA)
Cytoplasm
Direct cellular penetration
In vitro
CCSCCSCTTTTSSCC
Additional Detail Fields 1 fields
CCSCCSCTTTTSSCC