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Peptide record

TPDB63017

P6 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB63017
P6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
Chemical: Linker 6-aminohexamoic acid (Ahx) N-terminal: Conjugation with FITC
Sequence
LLRARWRRRRSRRFR
Physicochemical Analysis
C92H161N43O17
NDCEQGHIKMPTYV
R
2141.57
13.30
9
0
5
+9
3.15
-2.000
58.67
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
256.82
1
Residue Composition
number
1
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
0
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
15
C92H161N43O17
2141.57
13.30
+9
3.15
-2.000
Free
Linker 6-aminohexamoic acid (Ahx)
L
Cationic
Linear
Conjugation with FITC
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (FITC)
Punctate cytoplasmic
High (compare to Tat)
In vitro
CCCCGGGGTSSCCCC
Additional Detail Fields 1 fields
CCCCGGGGTSSCCCC