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Peptide record

TPDB63012

Xentry peptides Cell-penetrating Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB63012
Xentry peptides
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 5-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
Sequence
LLLLR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C30H58N8O6
ANDCEQGHIKMFPSTWYV
L
626.84
11.05
1
0
4
+1
-0.95
2.140
312.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5 reviewed residue count
C30H58N8O6 sequence-only estimate (linear, free termini)
626.84 sequence-only estimate (linear, free termini)
11.05 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-0.95 sequence-only estimate (linear, free termini)
2.140 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HepG2, WM-266-4 and BT549

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (FITC- and TAMRA)
Cytoplasm
Lower efficiency
Probably Clathrin mediated endocytosis and is dependent on HSPG-decorated syndecan-4
In vitro
CCCCC
Additional Detail Fields 1 fields
CCCCC