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Peptide record

TPDB63007

Shuttle18 (S18) Cell-penetrating Peptides standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB63007
Shuttle18 (S18)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 32-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LLKLWSRLLKLWTQGGSGGGSGRRLKAKRAKA
Physicochemical Analysis
C157H270N52O38
NDCEHIMFPYV
L
3494.20
12.89
9
0
12
+9
1.23
-0.509
94.69
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
11000
314.81
5
Residue Composition
number
3
A
4
R
0
N
0
D
0
C
0
E
1
Q
6
G
0
H
0
I
7
L
5
K
0
M
0
F
0
P
3
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 6 H: 0 I: 0 L: 7 K: 5 M: 0 F: 0 P: 0 S: 3 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
32
C157H270N52O38
3494.20
12.89
+9
1.23
-0.509
Free
L
Amphiphilic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hae Cells And Nk Cells

Assay & Model

Adult BALB/c mice
Adult BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Synthetic
GFP protein. and SpCas9 or AsCas12a ribonucleoprotein (RNP)
Nucleus
In vitro and in vivo
CCCTHHHHHHHHTTTSSCSSSHHHHHGGGSCCCC
Additional Detail Fields 1 fields
CCCTHHHHHHHHTTTSSCSSSHHHHHGGGSCCCC