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Peptide record

TPDB62994

pVEC mutant Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB62994
pVEC mutant
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with fluorescein
Sequence
LLIILRRRIRKQAAAHSK-NH2
Physicochemical Analysis
C95H175N35O21
NDCEGMFPTWYV
R
2143.66
12.88
7
0
9
+6
3.77
-0.167
146.67
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
3
A
4
R
0
N
0
D
0
C
0
E
1
Q
0
G
1
H
3
I
3
L
2
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 3 L: 3 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C95H175N35O21
2143.66
12.88
+6
3.77
-0.167
Amidation
L
Amphipathic
Linear
Conjugation with fluorescein
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human bowes melanoma cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
Prabably cytoplasm and nucleus
Lower than pVEC
Receptor independent endocytic pathway
In vitro
CCCCCGGGHHHHSCCCC
Additional Detail Fields 1 fields
CCCCCGGGHHHHSCCCC