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Peptide record

TPDB62974

CVP1-N2 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB62974
CVP1-N2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
LKRLRRRYKFRHRRRQRYRRR
Physicochemical Analysis
C134H234N62O25
ANDCEGIMPSTWV
R
3113.73
12.88
15
0
5
+14
9.11
-2.890
37.14
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
2980
95.71
3
Residue Composition
number
0
A
12
R
0
N
0
D
0
C
0
E
1
Q
0
G
1
H
0
I
2
L
2
K
0
M
1
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 2 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
21
C134H234N62O25
3113.73
12.88
+14
9.11
-2.890
Free
L
Cationic
Linear
Conjugated with FITC
N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

293T, Hct116, 3T3, And Mdck Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
pCDNA3.1-RFP plasmid and FITC dye
Nucleus
CVP1-N2 showed more efficient cellular uptake than CVP1 and TAT
Direct translocation
In vitro
CTTTTTHHHHSSHHHHHSCC
Additional Detail Fields 1 fields
CTTTTTHHHHSSHHHHHSCC