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Peptide record

TPDB62973

L4 Cell-penetrating Peptides standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB62973
L4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 29-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
LKRAIWLIKGSTSRDHMVLHEYVNAAGIT-NH2
Physicochemical Analysis
C147H239N43O40S1
CQFP
AIL
3280.84
10.19
6
2
14
+2
3.75
0.031
111.03
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
6990
213.06
6
Residue Composition
number
3
A
2
R
1
N
1
D
0
C
1
E
0
Q
2
G
2
H
3
I
3
L
2
K
1
M
0
F
0
P
2
S
2
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 3 R: 2 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 2 I: 3 L: 3 K: 2 M: 1 F: 0 P: 0 S: 2 T: 2 W: 1 Y: 1 V: 2
Chemical Descriptors
29
C147H239N43O40S1
3280.84
10.19
+2
3.75
0.031
Amidation
L
Hydrophobic
Linear
Conjugated with CF
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Hek293T, Jurkat E6.1 Leukemia Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Hydrophobic
Synthetic
carboxyfluorescein(CF) dye
Cytoplasm
Peptides L3 and L4 showed even less uptake
In vitro