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Peptide record

TPDB62971

Vaspin21−30 (VaspinN) Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB62971
Vaspin21−30 (VaspinN)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with TAMRA
Sequence
LKPSFSPRNY
Physicochemical Analysis
C56H85N15O15
ADCEQGHIMTWV
PS
1208.38
10.42
2
0
3
+2
0.75
-1.140
39.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
123.31
4
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
1
K
0
M
1
F
2
P
2
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 1 P: 2 S: 2 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
10
C56H85N15O15
1208.38
10.42
+2
0.75
-1.140
Free
L
Linear
Conjugated with TAMRA
N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

3T3-L1, Scat, Epiat, Imba, Hepg2 And Hek293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
TAMRA dye
Lysosomes
3T3-L1 cells to be >10-fold higher than in HEK293 cells. Rapid and efficient uptake of theVaspinN peptide in all cell lines
More than one endocytosis pathways including clathrin-mediated endocytosis and micropinocytosis
In vitro
CCSSSCSCCC
Additional Detail Fields 1 fields
CCSSSCSCCC