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Peptide record

TPDB62970

scrambled KIKKK Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB62970
scrambled KIKKK
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Acylation
Sequence
LKNKFKGVKLAEIEKQALKGTR
Physicochemical Analysis
C113H199N33O30
DCHMPSWY
K
2500.03
10.82
7
2
8
+5
8.56
-0.768
93.18
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
2
A
1
R
1
N
0
D
0
C
2
E
1
Q
2
G
0
H
1
I
3
L
6
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 0 E: 2 Q: 1 G: 2 H: 0 I: 1 L: 3 K: 6 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
22
C113H199N33O30
2500.03
10.82
+5
8.56
-0.768
Free
L
Cationic
Linear
Acylation
N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human Sperm

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
TAMRA labelled at N terminus
Cytoplasm
KIKKK accumulation appeared to exceed that of the scrambled peptide
In vitro
CCSSBTTTBTSCSSSCCTTCSGGGSCSCC
Additional Detail Fields 1 fields
CCSSBTTTBTSCSSSCCTTCSGGGSCSCC