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Peptide record

TPDB62959

LK‐5 Cell-penetrating Peptides standard
93 amino acids
Basic Information
3D PDB MODEL
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TPDB62959
LK‐5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 93-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LKKLLKLLKKLLKLGGLKKLLKLLKKLLKLAGGSEFLKKLLKLLKKLLKLGGLKKLLKLLKKLLKLAGKSSDPNSSSLKKLLKLLKKLLKLAG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C496H917N125O105
RCQHIMTWYV
L
10312.51
11.47
31
2
44
+29
0.02
0.206
170.97
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
7
Residue Composition
number
3
A
0
R
1
N
1
D
0
C
1
E
0
Q
8
G
0
H
0
I
40
L
31
K
0
M
1
F
1
P
6
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 8 H: 0 I: 0 L: 40 K: 31 M: 0 F: 1 P: 1 S: 6 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
93 reviewed residue count
C496H917N125O105 sequence-only estimate (linear, free termini)
10312.51 sequence-only estimate (linear, free termini)
11.47 sequence-only estimate (linear, free termini)
+29 sequence-only estimate (linear, free termini)
0.02 sequence-only estimate (linear, free termini)
0.206 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Amphipathic Activity
Pentamer Activity
Free Activity
N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa and HEK 293T cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Pentamer L Amphipathic
Synthetic
TAMRA dye and Enhanced green fluorescence protein (eGFP)
Cytosol and Nucleus
Same as LK‐4–eGFP.
In vitro
CCCCTHHHHTTTCCCSSSSCCC
Additional Detail Fields 1 fields
CCCCTHHHHTTTCCCSSSSCCC