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Peptide record

TPDB62958

LK‐4 Cell-penetrating Peptides standard
68 amino acids
Basic Information
3D PDB MODEL
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TPDB62958
LK‐4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 68-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LKKLLKLLKKLLKLGGLKKLLKLLKKLLKLAGGSEFLKKLLKLLKKLLKLGGLKKLLKLLKKLLKLAG
Physicochemical Analysis
C373H694N92O72
RNDCQHIMPTWYV
L
7620.19
11.54
24
1
35
+23
6.59
0.401
186.47
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
1
E
0
Q
7
G
0
H
0
I
32
L
24
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 7 H: 0 I: 0 L: 32 K: 24 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
68
C373H694N92O72
7620.19
11.54
+23
6.59
0.401
Free
L
Amphipathic
Tetramer
Free
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa and HEK 293T cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Tetramer L Amphipathic
Synthetic
TAMRA dye and Enhanced green fluorescence protein (eGFP)
Cytosol and Nucleus
Increase of cell penetrating activities at LK‐3–eGFP and saturation after LK‐4–eGFP.
Macropinocytosis and energy-independent pathway
In vitro
CCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCC