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Peptide record

TPDB62957

LK‐3 Cell-penetrating Peptides standard
52 amino acids
Basic Information
3D PDB MODEL
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TPDB62957
LK‐3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 52-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LKKLLKLLKKLLKLGGLKKLLKLLKKLLKLAGGSEFLKKLLKLLKKLLKLAG
Physicochemical Analysis
C285H528N70O56
RNDCQHIMPTWYV
L
5831.76
11.41
18
1
27
+17
5.11
0.406
183.85
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
1
E
0
Q
5
G
0
H
0
I
24
L
18
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 5 H: 0 I: 0 L: 24 K: 18 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
52
C285H528N70O56
5831.76
11.41
+17
5.11
0.406
Free
L
Amphipathic
Trimer
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa and HEK 293T cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Trimer L Amphipathic
Synthetic
TAMRA dye and Enhanced green fluorescence protein (eGFP)
Cytosol and Nucleus
Increase of cell penetrating activities at LK‐3–eGFP and saturation after LK‐4–eGFP.
In vitro
CCCCSCSSSCBCSSCBC
Additional Detail Fields 1 fields
CCCCSCSSSCBCSSCBC