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Peptide record

TPDB62956

LK-4 Cell-penetrating Peptides modified_plain modified
68 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB62956
LK-4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 68-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Domain Z Fused N-terminal: Acetylation
Sequence
Ac-LKKLLKLLKKLLKLGGLKKLLKLLKKLLKLAGGFLGLKKLLKLLKKLLKLGGLKKLLKLLKKLLKLAG
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
68 reviewed residue count
Domain Z Fused Activity
L Activity
Amphipathic Activity
Tetramer Activity
Acetylation Activity
N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, A549, MDA-MB-231, Nih3T3, Caco-2

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Tetramer L Amphipathic
Synthetic
TAMRA-labelled IgG
Cytoplasm and nucleus
LK-4-domain Z showed higher IgG delivery efficiency than LK-2-domain Z at every concentration point
Macropinocytosis, clathrin/caveolae-mediated endocytosis, or energy-independent penetration mechanisms
In vitro
CCCSSSSCBTTTBCSCC
Additional Detail Fields 1 fields
CCCSSSSCBTTTBCSCC