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Peptide record

TPDB62956

LK-4 Cell-penetrating Peptides standard
68 amino acids
Basic Information
3D PDB MODEL
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TPDB62956
LK-4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 68-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Domain Z Fused N-terminal: Acetylation
Sequence
Ac-LKKLLKLLKKLLKLGGLKKLLKLLKKLLKLAGGFLGLKKLLKLLKKLLKLGGLKKLLKLLKKLLKLAG
Physicochemical Analysis
C373H696N92O69
RNDCEQHIMPSTWYV
L
7574.20
11.86
24
0
36
+24
3.89
0.515
192.21
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
8
G
0
H
0
I
33
L
24
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 8 H: 0 I: 0 L: 33 K: 24 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
68
C373H696N92O69
7574.20
11.86
+24
3.89
0.515
Domain Z Fused
L
Amphipathic
Tetramer
Acetylation
N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, A549, MDA-MB-231, Nih3T3, Caco-2

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Tetramer L Amphipathic
Synthetic
TAMRA-labelled IgG
Cytoplasm and nucleus
LK-4-domain Z showed higher IgG delivery efficiency than LK-2-domain Z at every concentration point
Macropinocytosis, clathrin/caveolae-mediated endocytosis, or energy-independent penetration mechanisms
In vitro
CCCSSSSCBTTTBCSCC
Additional Detail Fields 1 fields
CCCSSSSCBTTTBCSCC