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Peptide record

TPDB62953

LK (7, 11) Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB62953
LK (7, 11)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Acetylation
Sequence
Ac-LKKLLKCLKKCLKLAG
Physicochemical Analysis
C83H158N22O17S2
RNDEQHIMFPSTWYV
LK
1800.42
10.54
6
0
7
+6
1.94
0.362
152.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
125
6.94
2
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
6
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 6 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C83H158N22O17S2
1800.42
10.54
+6
1.94
0.362
Free
L
Amphipathic
Linear
Acetylation
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, CHO-K1, Hek 293T, MDA-MB-231

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
5-carboxytetramethylrhodamine (TAMRA)
Showed only limited penetration (approximately 15%) at 100 nM
In vitro
CCCCCCC
Additional Detail Fields 1 fields
CCCCCCC