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Peptide record

TPDB62944

EB1 Cell-penetrating Peptides modified_plain modified
24 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB62944
EB1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
modified_plain
Yes
A 24-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
C-terminal: Addition of Cysteine
Sequence
LIRLWSHLIHIWFQNRRLKWKKKC
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
24 reviewed residue count
Addition of Cysteine Activity
L Activity
Amphipathic Activity
Linear Activity
Free Activity
N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO Cells

Assay & Model

Six-week-old male nude mice (BALB/c nu/nu) bearing NCI-N87 and PANC-1 tumors
Six-week-old male nude mice (BALB/c nu/nu) bearing NCI-N87 and PANC-1 tumors

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Indocyanine green (ICG)-labeled Lactosomes (A3B-type)
Endosomes and Lysosomes
EB1 > Pep1 > -CPP cellular uptake efficiency of CPP-modified lactosomes in CHO cells
In vitro and in vivo
CCTTTSCCSCCCCCCCSCSSCC
Additional Detail Fields 1 fields
CCTTTSCCSCCCCCCCSCSSCC