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Peptide record

TPDB62923

S-lycosin-I Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62923
S-lycosin-I
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 24-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LHEKLKEKAIFKAISKMAKFWGKR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C136H223N37O30S1
NDCQPTYV
K
2888.56
10.91
9
2
11
+6
1.62
-0.608
77.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
1.90
1
Residue Composition
number
3
A
1
R
0
N
0
D
0
C
2
E
0
Q
1
G
1
H
2
I
2
L
7
K
1
M
2
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 1 H: 1 I: 2 L: 2 K: 7 M: 1 F: 2 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
24 main sequence record
C136H223N37O30S1 sequence-only estimate (linear, free termini)
2888.56 sequence-only estimate (linear, free termini)
10.91 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
1.62 sequence-only estimate (linear, free termini)
-0.608 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic and amphiphilic Activity
Linear Activity
Free Activity
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa , Mat-Lylu Cells , Sw480, Hek293T, HUVEC And Hbl100 Cell Lines

Assay & Model

Healthy female 4 to 6 week-old BALB/c mice
Healthy female 4 to 6 week-old BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphiphilic
Synthetic
Gold nanoparticles (NRs)
Cytoplasm
Intracellular SLGNPs were significantly decreased compared to LGNPs but still higher penetrating activity than PGNPs
Clathrin and caveolae mediated endocytosis
In vitro and in vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC