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Peptide record

TPDB62923

S-lycosin-I Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62923
S-lycosin-I
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LHEKLKEKAIFKAISKMAKFWGKR
Physicochemical Analysis
C136H223N37O30S1
NDCQPTYV
K
2888.56
10.91
9
2
11
+6
6.29
-0.608
77.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
190.41
1
Residue Composition
number
3
A
1
R
0
N
0
D
0
C
2
E
0
Q
1
G
1
H
2
I
2
L
7
K
1
M
2
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 1 H: 1 I: 2 L: 2 K: 7 M: 1 F: 2 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
24
C136H223N37O30S1
2888.56
10.91
+6
6.29
-0.608
Free
L
Cationic and amphiphilic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa , Mat-Lylu Cells , Sw480, Hek293T, HUVEC And Hbl100 Cell Lines

Assay & Model

Healthy female 4 to 6 week-old BALB/c mice
Healthy female 4 to 6 week-old BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphiphilic
Synthetic
Gold nanoparticles (NRs)
Cytoplasm
Intracellular SLGNPs were significantly decreased compared to LGNPs but still higher penetrating activity than PGNPs
Clathrin and caveolae mediated endocytosis
In vitro and in vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC