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Peptide record

TPDB62922

hCT (9–32) Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62922
hCT (9–32)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with fluorescein
Sequence
LGTYTQDFNKFHTFPQTAIGVGAP-NH2
Physicochemical Analysis
C121H176N30O35
RCEMSW
T
2610.91
7.75
2
1
9
+0
0.78
-0.212
52.92
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
57.07
8
Residue Composition
number
2
A
0
R
1
N
1
D
0
C
0
E
2
Q
3
G
1
H
1
I
1
L
1
K
0
M
3
F
2
P
0
S
4
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 2 G: 3 H: 1 I: 1 L: 1 K: 1 M: 0 F: 3 P: 2 S: 0 T: 4 W: 0 Y: 1 V: 1
Chemical Descriptors
24
C121H176N30O35
2610.91
7.75
+0
0.78
-0.212
Amidation
L
Linear
Conjugation with fluorescein
N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Calu-3 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (fluorescein)
Extracellular distribution
In vitro
CCCSHHHHTTSCCCCCCCCCSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

TR146 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Fluorophore (fluorescein)
Both punctuated cytoplasmic (vesicles) and extracellular distribution
In vitro
CCCSHHHHTTSCCCCCCCCCSCC
Additional Detail Fields 1 fields
CCCSHHHHTTSCCCCCCCCCSCC