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Peptide record

TPDB62921

hCalcitonin-anti-gyrA PNA/scPNA Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB62921
hCalcitonin-anti-gyrA PNA/scPNA
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 23-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LGTYQDFNKFHTFPQTAIGVGAP
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C117H169N29O33
RCEMSW
GFT
2509.80
7.75
2
1
9
+0
0.66
-0.191
55.22
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
0.59
7
Residue Composition
number
2
A
0
R
1
N
1
D
0
C
0
E
2
Q
3
G
1
H
1
I
1
L
1
K
0
M
3
F
2
P
0
S
3
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 2 G: 3 H: 1 I: 1 L: 1 K: 1 M: 0 F: 3 P: 2 S: 0 T: 3 W: 0 Y: 1 V: 1
Chemical Descriptors
23 main sequence record
C117H169N29O33 sequence-only estimate (linear, free termini)
2509.80 sequence-only estimate (linear, free termini)
7.75 sequence-only estimate (linear, free termini)
+0 sequence-only estimate (linear, free termini)
0.66 sequence-only estimate (linear, free termini)
-0.191 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

S. Pyogenes Strains

Assay & Model

G. mellonella Larvae
G. mellonella Larvae

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
anti-gyrA antisense PNAs and scrambled PNAs [scPNAs]
In vitro and in vivo
CCCCGGGTSSCC
Additional Detail Fields 1 fields
CCCCGGGTSSCC