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Peptide record

TPDB62917

Tat (43-60) Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB62917
Tat (43-60)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
C-terminal: Conjugation with fluorescein maleimide N-terminal: Labelled with Cys-acetamidomethyl
Sequence
LGISYGRKKRRQRRRPPQ
Physicochemical Analysis
C96H170N40O23
ANDCEHMFTWV
R
2252.66
12.71
8
0
3
+8
7.24
-2.200
43.33
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
66.14
4
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
2
Q
2
G
0
H
1
I
1
L
2
K
0
M
0
F
2
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 2 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
18
C96H170N40O23
2252.66
12.71
+8
7.24
-2.200
Conjugation with fluorescein maleimide
L
Cationic
Linear
Labelled with Cys-acetamidomethyl
N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3
US 6740524

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (fluorescein)
Cytoplasm and nucleus, nucelolus
High
Non-endocytic mechanism
In vitro
CCTTCCTTTSSCCCCCCC
Additional Detail Fields 1 fields
CCTTCCTTTSSCCCCCCC