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Peptide record

TPDB62914

Cell-penetrating Peptides standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB62914
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 31-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: EBD_S11 fusion proteins
Sequence
LFVDKATPQIYYTPCESVTVKSKGKNRRKKS
Physicochemical Analysis
C159H263N45O46S1
HMW
K
3573.17
10.43
8
2
9
+6
9.45
-0.939
56.45
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
2980
83.40
11
Residue Composition
number
1
A
2
R
1
N
1
D
1
C
1
E
1
Q
1
G
0
H
1
I
1
L
6
K
0
M
1
F
2
P
3
S
3
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 1 C: 1 E: 1 Q: 1 G: 1 H: 0 I: 1 L: 1 K: 6 M: 0 F: 1 P: 2 S: 3 T: 3 W: 0 Y: 2 V: 3
Chemical Descriptors
31
C159H263N45O46S1
3573.17
10.43
+6
9.45
-0.939
Free
EBD_S11 fusion proteins
L
Linear
Free
N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hcc-827, Hek-293 , A431, CHO-K1 , Hl-60, Amo-1, T47D Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
GFP1–10 plasmid
Cytoplasm
Dose-dependent uptake
In vitro
CCCSSHHHHHHHHHTTSCCCSCCCCCSCCCGGGGGCC
Additional Detail Fields 1 fields
CCCSSHHHHHHHHHTTSCCCSCCCCCSCCCGGGGGCC