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Peptide record

TPDB62912

peptide 15 Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB62912
peptide 15
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Lysine
Sequence
LEQLLRLKK
Physicochemical Analysis
C52H97N15O13
ANDCGHIMFPSTWYV
L
1140.43
10.59
3
1
4
+2
3.15
-0.456
173.33
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
0
I
4
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 0 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C52H97N15O13
1140.43
10.59
+2
3.15
-0.456
Addition of Lysine
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells And J774.2 Mouse Macrophage Cell Lines.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
5-FAM at C terminal
Cytoplasm
All the peptides tested were internalised into the cells
Endocytosis
In vitro
CCSCGGGGCCCC
Additional Detail Fields 1 fields
CCSCGGGGCCCC