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Peptide record

TPDB62909

CPP-Ts Cell-penetrating Peptides standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB62909
CPP-Ts
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 45-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LDEESLRKECNHLNEPCDSDGDCCTSSEQCISTGSKYFCKGKQGP
Physicochemical Analysis
C199H314N58O77S6
AMWV
CS
4943.38
4.39
6
9
6
-4
19.25
-1.053
34.67
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1865
37.73
19
Residue Composition
number
0
A
1
R
2
N
4
D
6
C
5
E
2
Q
4
G
1
H
1
I
3
L
4
K
0
M
1
F
2
P
6
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 4 C: 6 E: 5 Q: 2 G: 4 H: 1 I: 1 L: 3 K: 4 M: 0 F: 1 P: 2 S: 6 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
45
C199H314N58O77S6
4943.38
4.39
-4
19.25
-1.053
Free
L
Hydrophilic
Linear
Free
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Cardiomyocytes

Assay & Model

Swiss mice (n=7, 6–8 weeks old, 24–28 g)
Swiss mice (n=7, 6–8 weeks old, 24–28 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophilic
Synthetic
Nucleus
It showed a diffuse localization in cardiomyocytes with an internalization time of 1 min, at 10 min it was concentrated in the perinuclear region, and it was finally almost completely internalized into the cell nucleus within 20 min.
In vitro and in vivo
CCCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCCC