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Peptide record

TPDB62886

D4 Cell-penetrating Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB62886
D4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 6-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Liquid crystalline nanodispersion (LCN)
Sequence
LARLLT
Physicochemical Analysis
C31H59N9O8
NDCEQGHIKMFPSWYV
L
685.86
11.05
1
0
4
+1
-0.90
1.333
211.67
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
0
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C31H59N9O8
685.86
11.05
+1
-0.90
1.333
Free
Liquid crystalline nanodispersion (LCN)
L
Cationic
Linear
Free
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A431 Cells

Assay & Model

Male hairless mice (HRS/J, 4–6 weeks old)
Male hairless mice (HRS/J, 4–6 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Lipoic acid (LA)
Cytoplasm
3-fold higher penetration compared with LCN-FITC
In vitro and in vivo
CCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCC