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Peptide record

TPDB62875

GALA3–EGFP–HBP Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB62875
GALA3–EGFP–HBP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
LAEALAEALEALAA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C60H102N14O21
RNDCQGHIKMFPSTWYV
A
1355.55
3.03
0
3
11
-3
-0.85
1.236
161.43
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
7
A
0
R
0
N
0
D
0
C
3
E
0
Q
0
G
0
H
0
I
4
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 7 R: 0 N: 0 D: 0 C: 0 E: 3 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14 main sequence record
C60H102N14O21 sequence-only estimate (linear, free termini)
1355.55 sequence-only estimate (linear, free termini)
3.03 sequence-only estimate (linear, free termini)
-3 sequence-only estimate (linear, free termini)
-0.85 sequence-only estimate (linear, free termini)
1.236 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
EGFP and HBP
Cytoplasm
Intracellular fluorescence HeLa cells co-incubated with the GALA3–EGFP–HBP fusion protein was not only strong but also had a very prominent cytoplasmic dispersion
Endocytosis
In vitro
CCGGGTTTTC
Additional Detail Fields 1 fields
CCGGGTTTTC