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Peptide record

TPDB62870

KY Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB62870
KY
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
KYRSGAITIGY-NH2
Physicochemical Analysis
C56H89N15O16
NDCEQHLMFPWV
GIY
1228.41
10.08
2
0
5
+2
-0.58
-0.227
80.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
2980
242.59
4
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
0
L
1
K
0
M
0
F
0
P
1
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 0 K: 1 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
11
C56H89N15O16
1228.41
10.08
+2
-0.58
-0.227
Amidation
L
Cationic
Linear
Free
NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293T Human Embryonic Kidney Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
SV40-pGL3 plasmid labelled with PicoGreen
Cytoplasm and nucleus
KK–DNA and KY–DNA complexes had their highest transfection efficacy at a DNA/peptide ratio of 1:5000, while decreasing the peptide concentration to a 1:312 ratio led to decreased transfection efficacy for both peptides.
In vitro
CCCBTTBCCCCSSCCCCCCCSSCCCCC
Additional Detail Fields 1 fields
CCCBTTBCCCCSSCCCCCCCSSCCCCC