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Peptide record

TPDB62869

KK Cell-penetrating Peptides modified_plain modified
11 amino acids
Basic Information
3D PDB MODEL
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Sequence-matched coordinates; source-recorded chemical modifications are not verified in this model.

TPDB62869
KK
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 11-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
KYKGAIIGNIK-NH2
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
11 main sequence record
Amidation Activity
L Activity
Cationic Activity
Linear Activity
Free Activity
N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293T Human Embryonic Kidney Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
SV40-pGL3 plasmid labelled with PicoGreen
Cytoplasm and nucleus
KK–DNA and KY–DNA complexes had their highest transfection efficacy at a DNA/peptide ratio of 1:5000, while decreasing the peptide concentration to a 1:312 ratio led to decreased transfection efficacy for both peptides.
In vitro
CCCCSSCCSCC
Additional Detail Fields 1 fields
CCCCSSCCSCC