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Peptide record

TPDB62864

6aKC Cell-penetrating Peptides modified_plain modified
22 amino acids
Basic Information
3D PDB MODEL
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TPDB62864
6aKC
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 22-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-KXKKBKKXKYQFLIKXKBKXKB-NH2
Physicochemical Analysis
C95H170N26O18
ARNDCEGHMPSTWV
K
1964.56
11.13
10
0
4
+10
7.54
-1.486
35.45
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
75.84
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
1
L
10
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 10 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
22
C95H170N26O18
1964.56
11.13
+10
7.54
-1.486
Amidation
Modified
Linear
Acetylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Immortalized Myod-Inducible (Doxycycline) Dm1

Assay & Model

Homozygous transgenic HSALR (line 20 b) mice
Homozygous transgenic HSALR (line 20 b) mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified
PMO against miR23b and PMO against miR-220
Nucleus
At 1,000 nM concentration, inducing a 1.5-fold change for 6aKC-218 and a 2-fold increase in MBNL1 for 6aKC-23b.
Gymnotic delivery
In vitro and in vivo