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Peptide record

TPDB62864

6aKC Cell-penetrating Peptides modified_plain modified
22 amino acids
Basic Information
3D PDB MODEL
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Sequence-matched coordinates; source-recorded chemical modifications are not verified in this model.

TPDB62864
6aKC
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 22-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-KXKKBKKXKYQFLIKXKBKXKB-NH2

Source notation is retained verbatim; residue identity and the source-provided length have not been independently validated.

Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
22 main sequence record
Amidation Activity
Modified Activity
Linear Activity
Acetylation Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Immortalized Myod-Inducible (Doxycycline) Dm1

Assay & Model

Homozygous transgenic HSALR (line 20 b) mice
Homozygous transgenic HSALR (line 20 b) mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified
PMO against miR23b and PMO against miR-220
Nucleus
At 1,000 nM concentration, inducing a 1.5-fold change for 6aKC-218 and a 2-fold increase in MBNL1 for 6aKC-23b.
Gymnotic delivery
In vitro and in vivo