Back to search

Peptide record

TPDB62863

9b2KC Cell-penetrating Peptides modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB62863
9b2KC
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 18-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-KXKKBKKFQILYKBKXKC-NH2
Physicochemical Analysis
C86H151N23O17S1
ARNDEGHMPSTWV
K
1811.35
10.78
8
0
4
+8
5.32
-1.244
43.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
82.26
3
Residue Composition
number
0
A
0
R
0
N
0
D
1
C
0
E
1
Q
0
G
0
H
1
I
1
L
8
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 8 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
18
C86H151N23O17S1
1811.35
10.78
+8
5.32
-1.244
Amidation
Modified
Linear
Acetylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Immortalized Myod-Inducible (Doxycycline) Dm1

Assay & Model

Homozygous transgenic HSALR (line 20 b) mice
Homozygous transgenic HSALR (line 20 b) mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified
Fusogenic
PMO against miR23b and PMO against miR-219
Nucleus
9b2KC-23b peaked at 3-fold change at 200 nM and 9b2KC-218 reached almost a 6-fold increase in MBNL1 at only 10 nM concentration.
Gymnotic delivery
In vitro and in vivo