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Peptide record

TPDB62854

[KW]5-E8 Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB62854
[KW]5-E8
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KWKWKWKWKWEEEEEEEE
Physicochemical Analysis
C125H168N28O35
ARNDCQGHILMFPSTYV
E
2622.88
4.47
5
8
5
-3
11.86
-2.889
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
27500
1048.47
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
8
E
0
Q
0
G
0
H
0
I
0
L
5
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 8 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
18
C125H168N28O35
2622.88
4.47
-3
11.86
-2.889
Free
L
Anionic and amphiphilic
Hybrid (Cyclic and Linear)
Free
N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Hybrid (Cyclic and Linear) L Anionic and amphiphilic
Synthetic
FITC labelled
Cytoplasm and nucleus
Concentration-dependent internalization
In vitro
CCCCHHHHHHHHHHHGGGSSCCGGGGGTTCC
Additional Detail Fields 1 fields
CCCCHHHHHHHHHHHGGGSSCCGGGGGTTCC