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Peptide record

TPDB62849

Shuttle10 (S10) Cell-penetrating Peptides standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB62849
Shuttle10 (S10)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 34-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KWKLARAFARAIKKLGGSGGGSYARALRRQARTG
Physicochemical Analysis
C161H272N58O40
NDCEHMPV
A
3660.30
12.71
10
0
14
+10
2.76
-0.638
66.47
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
6990
190.97
5
Residue Composition
number
7
A
6
R
0
N
0
D
0
C
0
E
1
Q
6
G
0
H
1
I
3
L
4
K
0
M
1
F
0
P
2
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 7 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 6 H: 0 I: 1 L: 3 K: 4 M: 0 F: 1 P: 0 S: 2 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
34
C161H272N58O40
3660.30
12.71
+10
2.76
-0.638
Free
L
Amphiphilic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hae Cells And Nk Cells

Assay & Model

Adult BALB/c mice
Adult BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Synthetic
GFP protein. and SpCas9 or AsCas12a ribonucleoprotein (RNP)
Nucleus
At a 20 μM concentration, S10 achieved the greatest GFP delivery. The S10 transduction efficiency ranged from 27 to 35% for all cell types of the surface epithelium (32 ±2.0, mean ± SE, n = 3).
In vitro and in vivo
CCCCTTTTSSCC
Additional Detail Fields 1 fields
CCCCTTTTSSCC