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Peptide record

TPDB62848

L-PenetraMax PenetraMax Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB62848
L-PenetraMax PenetraMax
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KWFKIQMQIRRWKNKR
Physicochemical Analysis
C104H168N34O20S1
ADCEGHLPSTYV
K
2246.75
12.72
7
0
6
+7
2.29
-1.731
48.75
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
489.60
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C104H168N34O20S1
2246.75
12.72
+7
2.29
-1.731
Free
L
Cationic Amphipathic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 6 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Male Sprague Dawley rats
Male Sprague Dawley rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Protein (Insulin)
Increasing concentrations of PenetraMax (0.5 or 2mM) enhanced the permeability of the nasal mucosa to insulin more markedly than L-penetratin and insulin alone
In vivo
CCCCCSSCGGGTCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Intestinal Loops Of Sprague Dawley Rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Insulin
L- and D-PenetraMax show greatest increase in ileum insulin absorption than other CPP
In Situ
CCCCCSSCGGGTCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Sf9 And Rp-Hzgut-Aw1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L
Synthetic
STAR635P fluorophore
Lysosomes
Rapid uptake of CPP through endosomes as Fluorescent vesicles were observed in as little as 20 min.
Endocytosis
In vitro and ex vivo
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Nanoparticles and FITC labelled dextrans
R8 and Tat increased the uptake of 200-nm nanoparticles by Caco-2 cells to 2.1-3.0 times that was similar or superior than penetratin and PenetraMax
In vitro
CCCCCCCC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Seven-week-old male ddY mice weighing 35–40 g
Seven-week-old male ddY mice weighing 35–40 g

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Synthetic
Insulin
Showed relatively continuous enhancement effects but less than D-penetratin
In vivo
CTTTSCCCCHHHHHTGGGGTC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 Cells Bacteroidetes (Bacteroides Vulgatus And Bacteroides Thetaiotaomicron), Firmicutes (Lactobacillus Gasseri, Latilactobacillus Sakei, And Clostridium Bolteae), Actinomicetya (Bifidobacterium Longum, And Bifidobacterium Adolescentis) , Proteobacteria (Escherichia Coli Nissle 1917 And Escherichia Coli K12) And Saccharomyces Boulardii

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
FITC-dextran
In vitro
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCSSCGGGTCCCC CCCCCCCC CTTTSCCCCHHHHHTGGGGTC CCCCCCCCC